This study aims to evaluate effects of magnesium sulfate on onset and duration of low dose rocuronium, intubation condition and surgical condition in patients undergoing laparoscopic cholecystectomy.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
75
Patients in each group receive Magnesium sulfate 30 mg/kg in 0.9% normal saline (total volume 100 ml) intravenously for 5 min before induction of anesthesia
Patients in each group receive 0.9% normal saline (total volume 100 ml) alone intravenously for 5 min before induction of anesthesia
0.6 mg/kg of Rocuronium given with induction of anesthesia
Assiut University Hospitals
Asyut, Asyut Governorate, Egypt
The time of onset the action of Rocuronium
by using the TOF watch nerve stimulator
Time frame: Time from injection of Rocuronium till T1 suppression more than 95% up to 10 minutes.
The time at which Maximal suppression
by using the TOF watch nerve stimulator
Time frame: Time from the injection of Rocuronium to T1 maximal suppression time (TOF=0) up to an hour.
Reversal of Rocuronium
by using the TOF watch nerve stimulator
Time frame: Time from injection of Rocuronium till reversal of T1 (TOF=25%) around an hour after induction of anesthesia
Intubation condition
to score intubation condition on the basis of 6 items: Jaw relaxation, laryngoscopy, vocal cord position, moving of limbs, coughing \& change in heart rate.
Time frame: Within 10 minutes after induction of anesthesia
Surgical condition
to score a surgical condition according to 7 point likert scale
Time frame: During surgery
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0.45 mg/kg of Rocuronium given with induction of anesthesia