Serelaxin To Lower Portal Pressure

Inclusion Criteria: 1. Male or female adult subjects over 18 years of age 2. Able to provide written informed consent and able to understand and willing to comply with the requirements of the study 3. Clinical imaging-diagnosed or biopsy-proven liver cirrhosis of any aetiology 4. Evidence of portal hypertension either on imaging or previous endoscopy 5. Patients with large/grade 3 varices as identified by endoscopy within 6 months of screening must be in an endoscopic band ligation programme at the time of study entry 6. Suspected hepatic venous pressure gradient (HVPG) ≥10 mmHg at baseline Exclusion Criteria: 1. Pregnancy or breast feeding 2. Women of child-bearing potential not using highly effective methods of contraception 3. Severe liver failure defined by one of the following: Prothrombin activity \<40%, Bilirubin \>5 mg/dL (85umol/L), hepatic encephalopathy \> grade I 4. A history of variceal bleed within 1 month prior to visit 1 5. Presence of any non-controlled and clinically significant disease that could affect the study outcome or that would place the patient at undue risk 6. Hepatocellular carcinoma or history of malignancy of any organ system (other than localized basal cell carcinoma of the skin) treated or untreated 7. Portal vein thrombosis 8. Previous surgical shunt or TIPSS 9. Current use of beta-blockers or nitrates, any other drug therapy known to have an influence on portal pressure (diuretics permitted provided patients have been on a stable dose for at least 30 days) 10. History of drug or alcohol abuse within 1 month of enrolment 11. Sitting Systolic Blood Pressure \<110 mmHg at screening visit or within 10 minutes prior to starting study drug infusion 12. Use of other investigational drugs within 5 half-lives of enrolment, or within 30 days/until the expected pharmacodynamic effect has returned to baseline, whichever is longer 13. Significant arrhythmias, which include any of the following: sustained ventricular tachycardia, bradycardia with sustained ventricular rate \< 45 beats per minute or atrial fibrillation/flutter with sustained ventricular response of \> 90 beats per minute at rest, or Long QT syndrome or corrected QT interval (QTc) \> 450 msec (QT correction will be performed using the Fridericia correction method: QTcF = QT/RR0.33) for males and \> 460 msec for females at screening visit 14. Documented hypersensitivity to intravenous contrast agents and/or iodine 15. Severe renal impairment (eGFR\<30mL/min /1.73m2) 16. Significant left ventricular outflow tract obstructions (e.g., severe valvular aortic stenosis, obstructive cardiomyopathy), severe mitral stenosis, restrictive amyloid myocardiopathy, acute myocarditis 17. Severe aortic insufficiency or severe mitral regurgitation for which surgical or percutaneous intervention is indicated 18. Major neurologic event including cerebrovascular events, within 30 days prior to screening 19. Clinical evidence of acute coronary syndrome currently or within 30 days prior to enrolment 20. History of hypersensitivity to study drug serelaxin or study drug ingredients 21. Inability to follow instructions or comply with follow-up procedures. 22. Permanent pacemaker, cardiac resynchronisation device or implantable cardioverter-defibrillator in situ