This is a single center pilot study evaluating the immediate effects of low-dose acetazolamide on respiratory control in subjects with treatment emergent sleep disordered breathing. The purpose of this study is to assess the immediate effect one-time low-dose acetazolamide on sleep breathing in (Treatment Emergent Sleep Disordered Breathing) TE-CSA subjects compared to subjects' baseline evaluation without acetazolamide. Investigators will also try to determine the immediate effect of one-time low-dose acetazolamide on subjects' resting ventilation and ventilatory response slope compared to subjects' baseline evaluation without acetazolamide.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Two single dose administrations of acetazolamide (once before daytime testing, and once before nighttime testing)
New York University School of Medicine
New York, New York, United States
Severity of Obstructive Sleep Apnea before and after acetazolamide administration using Laboratory Nocturnal Polysomnography
Time frame: 60 Days
Total lung capacity before and after acetazolamide administration
Time frame: 60 Days
Gas composition with and without acetazolamide using Resting Ventilation Study (RVS)
Time frame: 20 Minutes
Measure of ventilatory response to carbon dioxide (CO2) without and with acetazolamide
Time frame: 15 Minutes
Measurement of Arterial Blood Gas (ABG)
Time frame: 60 Days
Measurement of Venous Blood (VB) Analysis
Time frame: 60 Days
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