The objective of the present work was to evaluate the antihypertensive effect associated with the consumption of fermented milk with Lactococcus lactis NRRL-B50571 on prehypertensive subjects.
A double-blind randomized controlled clinical study of an 8-week intervention with 36 hypertensive subjects was carried out to evaluate the antihypertensive effect of fermented milk with Lactococcus lactis NRRL-B50571. Once obtained the informed consent; volunteers were randomized into two groups (n=18) to either receive 150 mL daily: fermented milk with Lactococcus lactis NRRL-B50571 (intervention group) or artificially acidified milk as control (placebo). Both drinks were consumed daily. Participants were asked not to change their diet or lifestyle during the intervention. We applied intention to treat for those participants who did not have good adherence and those who withdraw the study. The outcomes between groups were analyzed using an independent sample Student t test, with a P value of 0.05 or less (two sided) when there was statistical significance; using statistical software.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
36
150 mL daily of fermented milk with Lactococcus lactis NRRL-B50571
150 mL daily of artificially acidified milk
Systolic Blood Pressure Measurements
From randomization (baseline), eight weeks of intervention and two weeks after intervention was over.
Time frame: Baseline to 10 weeks
Diastolic Blood Pressure Measurements
From randomization (baseline), eight weeks of intervention and two weeks post-treatment.
Time frame: Baseline to 10 weeks
Total Cholesterol Measurements
Total cholesterol in baseline and after 8 weeks of treatment (Intake period).
Time frame: Baseline and 8th week
Low Density Lipoproteins Measurements
Low density lipoproteins measurements in baseline and after 8 weeks of treatment (intake period).
Time frame: Baseline and 8th week
High Density Lipoproteins
High density lipoproteins measurements in baseline and after 8 weeks of treatment (intake period).
Time frame: Baseline and 8th week
Triglycerides Measurements
Triglycerides measurements in baseline and after 8 weeks of treatment (intake period).
Time frame: Baseline and 8th week
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