Safety Study of CN-105 Neuroprotective Peptide for Intracerebral Hemorrhage

Inclusion Criteria: 1. Capable of giving written Informed Consent to participate in the study prior to undergoing any screening procedures. 2. Non-smoking and does not use nicotine-containing products (including smoking cessation aids, such as gums or patches) for 6 months or greater at study commencement 3. Adult male or female volunteers between 18 and 50 years (inclusive) at screening 4. BMI between 18-33 kg/m2 (inclusive) and weighing at least 110 lbs (50 kg). 5. Healthy on the basis of the medical history, physical examination, vital signs, ECG, blood chemistry, hematology, and urinalysis performed at screening. 6. Adequate peripheral forearm vein access. 7. No significant dietary restrictions and willing to fully consume all Duke CRU "Regular Diet" meals and beverages/water provided to them. 8. No prescription medication except contraception as described in Inclusion #10 within 7 days or 5 half-lives (whichever is longer) of study entry (randomization and initiation of study drug administration) or any over-the-counter (OTC) medication or herbal/vitamin supplement within 7 days of study entry, and not expected to require or take any prescription or over-the-counter medication or supplement for the full duration of the study. Acetaminophen at doses of ≤1 g/day may be used and stable treatment for seasonal allergies (other than glucocorticoids via any route) may be used. Limited use of non-prescription medications that are not believed to affect subject safety or the overall results of the study may be permitted on a case by case basis following approval by the sponsor. 9. Women who are of non-childbearing potential, must be: Surgically sterile (removal of both ovaries and/ or uterus at least 12 months prior to dosing). Naturally postmenopausal (spontaneous cessation of menses) for at least 24 consecutive months prior to dosing on Day -1 and with an FSH level at screening of ≥ 40 mIU/mL. 10. Women of child-bearing potential must have a negative serum pregnancy test at screening and urine pregnancy test during the study, and must agree to avoid pregnancy during study and for three months after the last dose of study drug. Pregnancy is tested at screening, during check-in, during the follow-up visit, and at any given point if deemed necessary to the PI or designate. During treatment, women of child-bearing potential must use two acceptable methods of contraception at the same time unless the subject has had a documented tubal sterilization or chooses to use a Copper T 380A IUD or LNG 20 IUS, in which case no additional contraception is required. Medically acceptable contraceptives include: (1) documented surgical sterilization (such as a hysterectomy), (2) barrier methods (such as a condom or diaphragm) used with a spermicide, (3) hormonal contraception (combination oral contraceptives, transdermal patch, injectables, implantables, or vaginal ring) or (4) an intrauterine device (IUD) or intrauterine system (IUS). Abstinence is not an acceptable form of contraception in this study. 11. Male participants must agree to take all necessary measures to avoid causing pregnancy in their sexual partners during the study and for three months after the last dose of study drug. Medically acceptable contraceptives include: (1) surgical sterilization (such as a vasectomy), or (2) a condom used with a spermicidal. Contraceptive measures such as Plan B (TM), sold for emergency use after unprotected sex, are not acceptable methods for routine use. 12. Must not have donated blood, platelets, or any other blood components 30 days, or plasma 90 days, prior to consenting. Must also agree not to donate blood, platelets, or any other blood components for 3 months after the last dose of study drug. 13. Male participants must agree not to donate sperm during the study and for 12 weeks after the last dose. 14. Subjects who are willing and able to comply with all scheduled visits, treatment plan, laboratory tests, and other study procedures. Exclusion Criteria: 1. Laboratory results outside the normal range, if considered clinically significant (CS) by the PI or delegate. Any laboratory result outside the normal range and not clinically significant will be designated as such by NCS (Non-clinically Significant). 2. Mental capacity that is limited to the extent that the participant cannot provide legal consent or understand information regarding the side effects of the study drug. 3. Currently abusing drugs or alcohol or with a history of drug or alcohol abuse within the past two years or drinks more than 3 cups of coffee per day. 4. Unwillingness or lack of ability to comply with the protocol, or to cooperate fully with the PI and site personnel. 5. Clinically significant ECG abnormality in the opinion of the PI or delegate. 6. Has taken any other investigational drug during the 30 days or 5 half-lives (whichever is longer) prior to the screening visit or is currently participating in another investigational drug clinical trial. 7. History or manifestation of clinically significant neurological (e.g., frequent headaches or migraines), gastrointestinal, renal, hepatic, cardiovascular, psychological, pulmonary, metabolic, endocrine, hematologic or other medical disorders that might influence the interpretation of the results of the study. 8. Infected with Hepatitis B or C or HIV Virus. 9. Participants who have a history of unexplained syncope or fainting from the collection of blood; i.e., autonomic dysfunction. 10. Lack of ability to understand verbal and/ or written English 11. Subjects who had significant trauma or surgical procedure within 1 month prior to Screening. 12. A positive urine drug screen or positive alcohol breathalyzer test.