Pilot Trial of Homebound Stem Cell Transplantation

Inclusion Criteria: * Diagnosis of Plasma cell dyscrasia * Treatment plan including Autologous HSCT * 18-80 years of age * Appropriate homebound setting as defined by one of the following: * Lodging at the MSK Residence. * Staying at home or a "home equivalent" in any one of the zip codes as outlined in the appendix. Home equivalent is defined as a residence which may or may not be the primary residence of the patient. * "Home equivalent" must pass the "Home Environment Screening Tool" for homebound stem cell transplantation (not required for other MSK recognized lodging facility). * Adequate caregiver support as defined by: * Single or multiple informal caregivers willing and able to provide 24 hour a day, seven day a week supervision of the transplant recipient in their home or "home-like" environment. * Caregiver willing and able to fulfill the basic stem cell transplant caregiver education requirements as determined by caregiver and healthcare team, including social worker * Have Wi-Fi connection * Appropriate third party payer coverage for "Homebound Stem Cell Transplant Program" * Both patient and caregiver willing to give and sign informed consent. Exclusion Criteria: * Patients with a documented active infection prior to starting their preparative regimen. This includes grade 3 or higher viral, bacterial, or fungal infection. * Uncontrolled arrhythmias * Active or uncontrolled pulmonary disease * Karnofsky Performance Scale (KPS) score \<80 * Sorror Co-morbidity index ≥ 4 except in patients with history of resected cancers * Creatinine clearance (calculated or measured) of \< 50 cc/minute * Inability of patient or caregiver to speak or read English (we currently do not have the manpower to translate nor staff a multilingual homebound stem cell transplant program with adequate educational materials). * Inadequate housing arrangements * Inadequate caregiver arrangements