The purpose of this study is to determine whether BMS-986141 is effective in reducing the recurrence of stroke in people who recently had a stroke, or a transient ischemic attack (known as a TIA or "mini stroke") and are receiving acetylsalicylic acid (also known as aspirin or ASA) to treat the stroke or TIA.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
16
Number of Participants With Composite of Symptomatic Ischemic Stroke by Day 28 and Unrecognized Brain Infarction Assessed by MRI at Day 28
The incidence of a composite of symptomatic ischemic stroke by Day 28 and unrecognized brain infarction assessed by MRI at Day 28 was to be reported by arm in all treated participants.
Time frame: 28 Days
Percentage of Participants With Composite of Adjudicated Major Bleeding and Adjudicated Clinically Relevant Non-major (CRNM) Bleeding During the Treatment Period
The percentage of participants with composite of major bleeding and CRNM bleeding was to be reported. Point estimates and 95% CIs for event rates were to be presented by treatment, together with point estimates and 95% CIs for the difference of event rates between each BMS-986141 arm and placebo.
Time frame: Up to 90 days
Percentage of Participants With Major Adverse Cardiovascular Events (MACE)
MACE was defined as a composite of adjudicated recurrent stroke, myocardial infarction, or cardiovascular death. The percentage of treated participants experiencing these events at Day 90 was to be reported by arm.
Time frame: 90 days
Percentage of Participants With Adjudicated Symptomatic Recurrent Stroke (Including Fatal and Non-fatal)
The percentage of participants with adjudicated symptomatic recurrent stroke at Day 28 was to be reported by arm for all treated participants.
Time frame: Day 28
Percentage of Participants With Composite of Unrecognized Brain Infarction Assessed by MRI at Day 28 and MACE at Day 90
The percentage of participants with unrecognized brain infarction at Day 28 and MACE at Day 90 was to be reported by arm for all treated participants.
Time frame: Day 90
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Banner University Medical Ctr
Phoenix, Arizona, United States
Hoag Memorial Hospital
Newport Beach, California, United States
Local Institution
Newark, Delaware, United States
University Of Florida
Gainesville, Florida, United States
University Of Florida Hsc/Jacksonville
Jacksonville, Florida, United States
Florida Hospital
Orlando, Florida, United States
Intercoastal Medical Group
Sarasota, Florida, United States
Presence Saint Joseph Medical Center
Joliet, Illinois, United States
University Of Louisville
Louisville, Kentucky, United States
Local Institution
Baltimore, Maryland, United States
...and 23 more locations
Percentage of Participants Composite of Adjudicated Recurrent Ischemic Stroke, Myocardial Infarction, or Cardiovascular Death
The percentage of treated participants with composite of adjudicated recurrent ischemic stroke, myocardial infarction, or cardiovascular death was reported by arm.
Time frame: Day 90