The purpose of this study is to measure diagnostic performance of ultrasound shear wave elastography to detect advanced hepatic fibrosis.
Hepatic fibrosis causes liver dysfunction and HCC. Since hepatic fibrosis is reversible dynamic condition, its monitoring is important to predict long term outcome and to determine treatment plan. The reference of standard to diagnose hepatic fibrosis is biopsy, but recently non-invasive method such as stiffness imaging has been drawing a lot of attention. In this study, ultrasound shear wave elastography will be performed and its diagnostic performance to detect advanced hepatic fibrosis (= \> F2) will be measured using histologic grade as a reference.
Study Type
OBSERVATIONAL
Enrollment
140
ultrasound shear wave elastography is performed in GE ultrasound scanner according to guidelines of ultrasound elastography.
Seoul National University Hospital
Seoul, South Korea
diagnostic performance to detect advanced hepatic fibrosis
from ultrasound SWE to perform hepatic resection or percutaneous liver biopsy in patients (with histologic diagnosis)
Time frame: 1 month
interobserver agreement of ultrasound SWE
two observers perform ultrasound SWE on the same day in volunteers.
Time frame: 1 day
agreement with MR elastography
interval between US and MR elastography in patients with available MR elastography
Time frame: 1 month
Technical success rate
technical success or failure of US elastography using GE LOGIQ E9 scanner in ALL study population
Time frame: 6 months
Reliable measurement rate
reliable measurement rate (interquartile range of serial measurement/median LS value \<30%) in patients with technically successful US elastography
Time frame: 6 months
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