Evaluation of the Effect of Appropriate Sedation for Patients After Gastrectomy: A Prospective Randomised Controlled Study

Chinese Medical Association80 enrolled

Overview

To evaluate the efficacy and safety of appropriate postoperative sedation with dexmedetomidine for patients after gastrectomy. Prospective randomised controlled study was conducted from October 2015 and December 2015 among patients after gastrectomy. The investigators are going to enroll patients who received abdominal surgeries. One group receive sedative along with analgesic and the other group analgesic only for the other group on the first 24 hours after surgeries and follow up for 3 days.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Postoperative Sedation,Gastrectomy, Enhanced Recovery After Surgery

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 85 Years

Medical Language ↔ Plain English

Inclusion Criteria: * 18-85 years old * underwent gastrectomy in the hospital and operation duration lasted at least 2 hours Exclusion Criteria: * take part in other clinical trials * quinolone antibiotics intake 4 weeks prior to or within the study * NSAIDS intake within one month * history of peptic ulcer * respiratory insufficiency * renal insufficiency * acute hepatitis or severe liver disease (Child-Pugh class C) * pregnancy or lactation * abnormal ECG with clinical significance * uncontrolled hypotension * bleeding tendency or hematological diseases * untreated mechanical intestinal obstruction * unable to express or any kind of mental disease.

Outcomes

Primary Outcomes

postoperative pain assessed by Prince Henry Pain Scale

assessed by Prince Henry Pain Scale by investigators at 8:00 am after surgeries until discharge from ICU