The purpose of this study is to investigate the effect of MT-8554 on the pharmacokinetics of simvastatin and rosuvastatin in healthy subjects.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
OTHER
Masking
NONE
Enrollment
28
Investigational center
City Name, United Kingdom
Area under the plasma concentration-time curve (AUC) of rosuvastatin alone and in the presence of MT-8554.
Time frame: 72 hours post dose
Cmax of rosuvastatin alone and in the presence of MT-8554.
Time frame: 72 hours post dose
AUC of simvastatin/simvastatin acid alone and in the presence of MT-8554.
Time frame: 24 hours post dose
Cmax of simvastatin/simvastatin acid alone and in the presence of MT-8554.
Time frame: 24 hours post dose
Safety and Tolerability as measured by vital signs
Time frame: Up to Day 16
Safety and Tolerability as measured by number of participants with adverse events
Time frame: Up to Day 16
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