Cardiac arrhythmias are a well-recognized complication of anesthesia for laparoscopy. The aim of this study was to evaluate the efficacy of atropine sulfate for prevention of brad arrhythmia induced by repeated succinylcholine during gynecological laparoscopic surgery.
120 candidates, ASA 1 in the age range 18-40 years scheduled for elective diagnostic gynecological laparoscopic surgery were randomly assigned into 4 groups to receive either atropine sulfate or normal saline solution (as placebo).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Enrollment
120
Atropine (0.01 mg/kg) (1 ml) IM 30 minutes before induction of anesthesia
Atropine (0.01 mg/kg) intravenously (10 ml) 3 minutes before induction of anesthesia
Atropine (0.01 mg/kg) added to the second dose succinylcholine (1mg/kg) prepared to 5 ml syringe with normal saline
Faculty of Medicine
Asyut, Asyut Governorate, Egypt
Occurrence of bradycardia
heart rate less than 60 per minutes or decrease more than 30% of baseline reading
Time frame: within the first 2 hours during surgery
Nasopharyngeal secretion
suction of Nasopharyngeal secretion (ml) during and after extubation
Time frame: within the first 4 hours during surgery
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1 ml normal saline IM 30 minutes before induction of anesthesia
IV 10 ml normal saline 3 minutes before induction of anesthesia
Second dose succinylcholine (1 mg/kg) prepared to 5 ml syringe with normal saline