Fluid Responsiveness in Septic Shock Evaluated by Caval Ultrasound Doppler Examination

Charles University, Czech Republic60 enrolled

Overview

The study aims at clarification of venous collapsibility measures with real venous flow measurements during dynamic maneuver testing fluid responsiveness in septic shock patients.

Sedated and mechanically ventilated patients in septic shock will be enrolled in the study. A fine catheter with ultrasound doppler probe will be introduced into the central venous catheter already in place in superior vena cava. Doppler signal will be evaluated by console prototype (NILUS Medical) and continuous analysis of blood flow velocity respiratory variation will be performed. These values will be compared to standard hemodynamic monitoring parameters (central venous and arterial pressures) and to parameters acquired by transoesophageal (TOE) and transthoracic echocardiography.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Septic Shock Vein Collapsibility Intravascular Doppler Volume Responsiveness in Septic Shock

Interventions

passive leg raisingPROCEDURE

passive leg raising under echocardiographic monitoring with intravascular doppler in place

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients in severe sepsis or septic shock * intubation and mechanical ventilation * sedated patient without spontaneous respiratory efforts * central venous catheter in place inserted via right internal jugular vein * signed informed consent by family members Exclusion Criteria: * superior vena cava vascular anomaly * irradiation of neck or mediastinum in medical history * thrombosis of superior vena cava in medical history * atrial fibrillation or other irregular rhythm * permanent or external pacemaker * aggressive mechanical ventilation (PEEP above 10 cm H2O, Pmax above 30 cm H2O) * TOE contraindication (oesophageal varices, stricture, tumour, upper gastrointestinal bleeding) * Pericardial effusion, constrictive pericarditis * Moderate or severe valvular lesion * Severe systolic dysfunction of the left (EF less than 30%) or right ventricle (FAC less than 25%) * Intraabdominal pressure above 20 mmHg * Open chest * Obvious severe hypovolemia ( LVEDA\<5.5cm2/m2BSA)

Locations (1)

Dept of Anaesthesia and Intensive Care, General University Hospital, 1st Medical Faculty, Charles University

Prague, Czechia

RECRUITING

Outcomes

Primary Outcomes

Fluid responsiveness

Evaluation of fluid responsiveness, defined as 15% increase of cardiac output after reversible fluid challenge (using PLR - passive leg raise maneuver), by ultrasound doppler evaluation of superior vena caval blood flow respiratory variation.