The Relationship Between Clotting Factor VIII and Bleeding Adverse Reactions in Patients Under the Therapies of Thrombolysis, Anticoagulation and Anti-platelet

Inclusion Criteria: * Guidelines prepared by the diagnostic criteria(according to the diagnostic criteria of the Fourth National Stroke Conference prepared,have been more than one times skull CT and/or MRI)was confirmed for ischemic stroke,and requires the use of antithrombotic therapy(including thrombolysis, anticoagulation, antiplatelet) patients * Willing and able to comply with the study protocol and visits planned Exclusion Criteria: * At the same time the presence of other active malignancy. * There is known brain metastases or leptomeningeal metastases * Systemic active infection ( ie infection leads to body temperature ≥38 ℃) * The last 4 weeks there is a need drainage ascites, pleural effusion or pericardial fluid . * Clinically significant obstruction , pulmonary fibrosis , kidney failure , liver failure and other diseases. * Uncontrolled diabetes. * Severe / unstable angina, New York Heart Association (NYHA) class III or IV symptoms of congestive heart failure * there is other reason (not the antithrombotic drugs) caused by bleeding. * The presence of an autoimmune disease or a history of organ transplant patients require immunosuppressive therapy * Psychiatric presence may increase the risks associated with study participation or study drug , or may interfere with the interpretation of study results * Pregnant and lactating women * Bleeding disorders may exist on admission * The researchers added that the study is not appropriate to the circumstances