Effect of Probiotic on Rhinovirus Induced Colds

Inclusion Criteria: INCLUSION CRITERIA AT ENROLLMENT: * Subject must be 18-60 years of age. * Subject must read and sign a copy of the approved Consent Form * Subject must have a serum neutralizing antibody titer of less than or equal to 1:4 to rhinovirus type 39 INCLUSION CRITERIA AT DAY -28 • Female subjects must be using an effective birth control method. INCLUSION CRITERIA AT CHALLENGE: * Female subjects must be using an effective birth control method. Exclusion Criteria: * Antibiotic use within 3 months prior to day -28 * Female subjects with a positive urine pregnancy screen * History of use of probiotics in the preceding two weeks * Current cancer diagnosis or immunosuppressive therapy in the last 6 months * Any clinically significant abnormalities of the upper respiratory tract * Any clinically significant acute or chronic respiratory illness * Any clinically significant bleeding tendency by history * Hypertension that requires treatment with antihypertensive medications * History of angina or other clinically significant cardiac disease * Any medical condition that in the opinion of the Principal Investigator is cause for exclusion from the study * History of regular use (more than 3 days in 7) of tobacco products within the preceding two weeks * History of drug or alcohol abuse in the 6 months preceding the study EXCLUSION CRITERIA AT CHALLENGE: * Any upper respiratory infection or allergic rhinitis in the two weeks prior to the challenge * Female subjects with positive pregnancy screen prior to challenge * Any medical condition that in the opinion of the Principal Investigator is cause for exclusion from the study * Use of any anti-inflammatory (steroids or NSAIDs) or cough/cold or allergy preparation in the two weeks prior to the challenge