The study will be conducted over 18 months. The main objective of this study is to explore the relationships between autobiographical memory and specific cognitive measures, as well as emotional and behavioural measures in patients who have suffered a moderate to severe TBI. Secondary objectives are to assess the psychometric properties of a self-defining memories questionnaire and to characterize autobiographical memory in the TBI population.
A total of 40 participants (20 non-consecutive adults with a moderate or severe TBI and 20 volunteers with any history of neurological or psychiatric disease) will be recruited into the study. The duration of the protocol is 70 minutes. As regards the assessment, three questionnaires will be administered in order to evaluate self-defining memories, apathetic manifestations and anxio-depressive symptoms. In addition, four cognitive measures will be used to assess verbal episodic memory, working memory, cognitive flexibility and verbal fluency.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
32
Hôpital Raymond Poincaré
Garches, Île-de-France Region, France
self-defining memory score
self-defining memories will be measured using the self-defining memories questionnaire
Time frame: 20 minutes
verbal episodic memory score
verbal episodic memory will be measured using the California Verbal Learning Test
Time frame: 20 minutes
working memory score
working memory will be measured using verbal span task
Time frame: 10 minutes
cognitive flexibility score
cognitive flexibility will be measured using the Trail Making Test
Time frame: 5 minutes
verbal fluency score
verbal fluency will be measured using the verbal fluency task
Time frame: 5 minutes
apathy score
apathetic manifestations will be measured using the Apathy Evaluation Scale
Time frame: 5 minutes
anxio-depressive score
anxio-depressive symptoms will be measured using the Hospital Anxiety and Depression Scale
Time frame: 5 minutes
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