The investigator will evaluate the influence of lung protective ventilation on postoperative clinical outcome in pediatric patients. The hypothesis is that application of low tidal volume, intermittent alveolar recruitment and adequate positive end-expiratory pressure (PEEP) would be more beneficial than conventional ventilation in children.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
114
TV 4 ml/kg during one lung ventilation and 6 ml/kg during two-lung ventilation with PEEP of 6 cmH2O
TV 8 ml/kg during one lung ventilation and 10 ml/kg during two-lung ventilation without PEEP
Seoul national university hospital
Seoul, South Korea
The number of patients with pulmonary complication
The number of patients with pulmonary complication including atelectasis, pulmonary infiltration, pulmonary edema, pulmonary infection, pleural effusion and pulmonary embolism
Time frame: up to postoperative 7 days
The number of patients with desaturation
The number of patients with desaturation (SpO2 \< 90%)
Time frame: During surgery
The number of patients with extrapulmonary complication
Time frame: through study completion, an average of 1 year
Mean duration of mechanical ventilation
Time frame: through study completion, an average of 1 year
Mean duration of ICU stay
Time frame: through study completion, an average of 1 year
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