The Clinical Outcomes Following Transfer of Blastocysts Cultured From Thawed Cleavage Stage Embryos

Royan Institute220 enrolled

Overview

Recent improvements in cell culture systems have led to a shift in in vitro fertilization (IVF) practice from early cleavage stage embryo transfer (ET) to blastocyst transfer. Blastocyst culture and transfer could theoretically provide better synchronization between the embryo and the uterine endometrium. The purpose of this study is comparing pregnancy rates and implantation rate following transfer of thawed cleavage embryos and blastocysts cultured from thawed cleavage embryos.

The proposal of this study approved by our institutional review boards and institution's ethical committee, and all participants will sign a written consent before enter to study. All patients will be randomly divided into two groups of thawed cleavage embryo transfers and transfers of blastocysts from thawed cleavage embryos. Embryos will be transferred in hormone replacement cycles. Preparation of the endometrium will be started in the second day of menstruation and will be continued according to their transfer type (blastocyst or cleavage). βhCG will be assessed 14 days after embryo transfer. Treatment cycle outcomes will be compared between 2 groups.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

220

Conditions

Infertility

Interventions

Blastocyte TransferringPROCEDURE

Intra-uterine transferring of blastocyst from thawed cleavage embryo in infertile women.

Embryo TransferringPROCEDURE

Inta-uterine transferring of thawed cleavage embryo transfer in infertile women.

Eligibility

Sex: FEMALEMin age: 16 YearsMax age: 37 Years

Medical Language ↔ Plain English

Inclusion Criteria: * The patients with first type of infertility * Age ≤ 37 years * Long ovulation induction protocol Exclusion Criteria: * Any previous surgery on the uterus and ovaries * Uterine factor infertility * Sever Male factor infertility (TESE, TESA ،Oligoteratozoospermia) * Recurrent abortion * The women with poor ovarian reserve

Locations (1)

Royan Institute

Tehran, Iran

Outcomes

Primary Outcomes

Pregnancy Rate

Evaluation of pregnancy rate in women 4 weeks after embryos transfer (ET).

Time frame: 4weeks

Secondary Outcomes

Miscarriage Rate

Evaluation the miscarriage rate in women 14 days after embryo transfer (ET) with BHCG titration.

Time frame: 14 days

Implantation Rate

Evaluation the implantation rate in women 14 days after embryo transfer (ET) with BHCG titration..

Time frame: 14 days

Ongoing pregnancy rate

Evaluation the ongoing pregnancy rate in women 14 days after embryo transfer (ET) with BHCG titration..

Time frame: 14 days

Data from ClinicalTrials.gov

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