Efficacy of Temocillin in Urinary Tract Infection Due to ESBL Producing and AmpC Hyperproducing Enterobacteriaceae

Inclusion Criteria: * Age of at least 18 year old * Patient benefits from social security * Signed informed consent * A urinary tract infection due to a confirmed ESBL producing strain (detected by the use of a rapid diagnostic test applied on the urine) requiring parenteral antimicrobial therapy * Hospitalized patient * For women able to procreate: Use of an acceptable method of birth control throughout the study. Acceptable methods of birth control are: oral contraceptives, intrauterine device (IUD), diaphragm with spermicide and condom. (All forms of hormonal contraception are acceptable Exclusion Criteria: * Patient infected with a bacteria which is not an ESBL-producing or AmpC hyperproducing Enterobacteriaceae * Patients infected with a strain sensible to both fluoroquinolones and trimethoprim/sulfamethoxazole * Patients infected with a strain resistant to temocillin * Hospital-acquired urinary tract infection (defined as a urinary infection that occurred at least 48h post admission in the hospital) * Patients has received any dose of active antimicrobial therapy (an antibiotic to which the infecting bacterium is susceptible) in the last 48h (prior to enrolment) except ≤ 2 dose of gentamicin. * Patients presenting another site of infection than urinary (except onset of bacteraemia from urinary tract origin) due to Gram negative bacteria. * Patients needing concomitant antimicrobial therapy. * Septic shock * Children (up to 18 years old) * Women who is pregnant, breastfeeding, or expecting to conceive at any time during the study (pregnancy test will be conducted for woman without menopause) * Patients with any kind of urinary/bladder catheter (JJ ureteral probe, …) * Hypersensitivity to the active substance, to penicillins or to any other type of beta-lactam agent * Chronically dialyzed patients * Patients having a creatinine clearance \< 30 mL/min * Complete obstruction of the urinary tract * Perinephretic or intrarenal abscesses * Tutorship or curatorship patient * Patient unable to give his consent