Phase IV Clinical Trial to Evaluate the Efficacy and Safety of PlbCR and Aceclofenac in the Treatment of Patients With Osteoarthritis of the Knee

Inclusion Criteria: * both male and female who is over 35year-old and below 80year-old * patient who diagnosed as Kellgren \& Lawrence stage I\~III by X-ray * osteoarthritis patient who is stable within 3months form starting this clinical trial * patient who is over 40mm in 100mm Pain VAS at Visit 2 * patient who agreed to participate this clinical trial spontaneously Exclusion Criteria: * second osteoarthritis * patient who has inflammatory disease which can effect efficacy outcomes such as bursitis, tenosynovitis, rheumatoid arthritis, etc. * patient who diagnosed as gastric ulcer or GI disease by esophagogastroduodenoscopy * patient who had joint surgery within 12months form screening visit of this clinical trial or planned to operate in this clinical trial period * patient who has had artificial joint surgery of knee * malignant tumor patient * patient who has taken Psychopharmaceutical or Narcotic Analgesics over 3months continuously * patient who took steroid by oral, inhalation or intraarticular injection within 3months form screening visit of this clinical trial * patient who took intraarticular hyaluronic acid injection of knee within 2months form screening visit of this clinical trial * patient who cannot take NSAIDs because of disease or medicine * allergy of aspirin of other NSAIDs * patient who has to handle his/her pain by or for CABG * galactose intolerance, Lactose Intolerance or glucose-galactose malabsorption * inflammatory bowel disease such as ulcerative colitis or Crohn's disease * moderate renal disease * moderate hepatic disease * moderate hypertension(SBP=\>160mmHg, DBP=\>100mmHg) * female who consents to contracept * patient who is not appropriate for this clinical trial