Assessment of resting energy expenditure (REE) by indirect calorimetry (IC) in 1400 healthy individuals for arithmetical transformation into an bedside tool to estimate energy requirements in dietary practice (BASAROTs). A multinational, multicenter, prospective cross-sectional study.
The assessment of energy expenditure is the basic requirement for any nutritional therapy. Nevertheless, there is still no accurate, scientifically validated and practical bedside tool. The reference method for energy expenditure measurement is indirect calorimetry (IC). High costs, time requirements and the need for trained personal are main reasons for its limited use in clinical practice. Also arithmetical calculations, such as the Harris-Benedict equation, are not widely accepted. In general energy expenditure is often estimated by so called rules of thumbs, a method requiring only one multiplication with body weight (for example: 25 kcal/kg body weight). Sex, age and BMI are usually not considered, although they are independent predictors of energy expenditure. Thus, energy expenditure estimations are often inaccurate, especially in older and overweight/obese persons. Therefore, it is important to develop a bedside tool that is more accurate but simple enough to be accepted by practitioners. In 2004, the Austrian Society of Clinical Nutrition published the first BMI, aged and sex adapted rule of thumbs, called BASAROTs (BMI Age Sex Adjusted Rule Of Thumbs). Those were, however, based on results of the Harris Benedict equation. The main objective of the present study is, therefore, to replace the existing BASAROTs by BASAROTs based on actual measurements of resting energy expenditure by indirect calorimetry (IC-BASAROTs).
Study Type
OBSERVATIONAL
Enrollment
1,400
Technical University of Munich
Munich, Bavaria, Germany
RECRUITINGFulda University of Applied Sciences
Fulda, Hesse, Germany
RECRUITINGDietrich Bonheoffer Hospital of Neubrandenburg
Neubrandenburg, Mecklenburg-Vorpommern, Germany
resting energy expenditure (REE) (kcal)
Assessed by indirect calorimetry
Time frame: 15 minutes
blood pressure (mm Hg)
upper arm measurement by certified medical device
Time frame: one single (baseline) measurement under standardized conditions
Body temperature (°C)
measured axillar, by infra-red ear thermometer and non-contact thermoscan
Time frame: one single (baseline) measurement under standardized conditions
Heart rate (bpm)
measured by heart rate band and blood pressure device
Time frame: one single (baseline) measurement under standardized conditions
Body weight (kg)
measured by electronic scale integrated in BIA device
Time frame: one single (baseline) measurement under standardized conditions
Body height (m)
measured by digital stationary stadiometer
Time frame: one single (baseline) measurement under standardized conditions
Fat mass (FM) (kg)
measured by bioelectrical impedance analysis (BIA)
Time frame: one single (baseline) measurement under standardized conditions
Fat-free mass (FFM) (kg)
measured by bioelectrical impedance Analysis (BIA)
Time frame: one single (baseline) measurement under standardized conditions
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University of Applied Sciences Neubrandenburg
Neubrandenburg, Mecklenburg-Vorpommern, Germany
RECRUITINGProfil Institut for Metabolic Research
Mainz, Rhineland-Palatinate, Germany
RECRUITINGLeipzig University - Medical Center IFB AdiposityDiseases
Leipzig, Saxony, Germany
RECRUITINGFat-free mass index (FFMI) (kg/m²)
measured by bioelectrical impedance Analysis (BIA)
Time frame: one single (baseline) measurement under standardized conditions
Fat mass index (FMI) (kg/m²)
measured by bioelectrical impedance Analysis (BIA)
Time frame: one single (baseline) measurement under standardized conditions
Skeletal muscle mass (SMM) (kg)
measured by bioelectrical impedance Analysis (BIA)
Time frame: one single (baseline) measurement under standardized conditions
Total body water (TBW) (l)
measured by bioelectrical impedance Analysis (BIA)
Time frame: one single (baseline) measurement under standardized conditions
Extracellular water (ECW) (l)
measured by bioelectrical impedance Analysis (BIA)
Time frame: one single (baseline) measurement under standardized conditions
Resistance (R) (Ω)
measured by bioelectrical impedance Analysis (BIA)
Time frame: one single (baseline) measurement under standardized conditions
Reactance (Xc) (Ω)
measured by bioelectrical impedance Analysis (BIA)
Time frame: one single (baseline) measurement under standardized conditions
Phase angle (°)
measured by bioelectrical impedance Analysis (BIA)
Time frame: one single (baseline) measurement under standardized conditions
Waist circumference (cm)
measured by measuring tape
Time frame: one single (baseline) measurement under standardized conditions
International Physical Activity Questionnaire (IPAQ) short form
Time frame: one single (baseline) interview