Inflammatory Bowel Disease, including ulcerative colitis, is thought to result from an imbalance of pro-inflammatory and anti-inflammatory factors. As such, the majority of treatment options are directed at attempting to control the chronic inflammation and prolonging remission of clinical symptoms. Several studies have proven that curcumin has well-established anti-inflammatory properties. However, curcumin has poor bioavailability and prior studies have needed to use high concentrations in order to study the efficacy of the product. The investigators propose that a bio-enhanced preparation of curcumin will require a lower dosage to reach and affect its target tissue and will subsequently produce less adverse side effects.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
50
Each capsule is a bio-enhanced modification of curcumin (diferuloylmethane), which is a derivative of curcuma longa (rhizome extract)
Dosage is as instructed by patient's physician
Asian Institutes of Gastroenterology
Hyderabad, Telangana, India
RECRUITINGTime to induction of clinical remission in the treatment arm compared with time to induction of clinical remission in control arm
Clinical remission is recorded by a Partial Mayo Index score of 0-1
Time frame: 1 year
Time to induction of endoscopic remission in the treatment arm compared with time to induction of endoscopic remission in control arm
Endoscopic remission is defined as endoscopic mucosal healing, is recorded by Ulcerative Colitis Endoscopic Index of Severity (UCEIS) score of \<3
Time frame: 1 year
Percentage of patients in the treatment arm who experienced adverse events as compared with patients in the control arm
Time frame: 1 year
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