Is Eovist Suitable for Arterial-Phase MR Imaging of Liver

University of Michigan198 enrolled

Overview

To examine the quality of liver images produced when the contrast agent Eovist is used during MRI.

Researchers will review data from the Eovist MRI and compare the scan with previous MRI exams the patient had with the same or other contrast agents. To determine the efficacy of Eovist contrast agent in producing MRI images of the liver. We will monitor patients for any unusual symptoms (adverse events) when the contrast is given. Patients are asked to hold their breath during an MRI scan. Eovist may interfere with the "breath hold" which could result in more breathing artifacts (based on a qualitative scale) on arterial images when the patients are given Eovist vs. other contrast agents.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

198

Conditions

Liver Disease

Interventions

Eovist ContrastPROCEDURE

Subjects will undergo an MRI (magnetic resonance imaging) scan using the Eovist contrast agent. This MRI scan takes approximately 45minutes to 1 hour to complete.

Non Eovist ContrastPROCEDURE

Subjects will undergo an MRI (magnetic resonance imaging) scan using a contrast agent other than Eovist. This MRI scan takes approximately 45minutes to 1 hour to complete.

Eligibility

Sex: ALLMin age: 21 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. You have had a scheduled MRI(magnetic resonance imaging) scan using the contrast agent EOVIST. 2. Male and females 21 years of age or older. Exclusion Criteria: 1. Does not have a contraindication for MRI (e.g. cardiac pacemaker, ferromagnetic or metallic implants). 2. Pregnancy

Locations (1)

University of Michigan Hospital

Ann Arbor, Michigan, United States

Outcomes

Primary Outcomes

Scanning artifacts on MRI with Eovist

To qualitatively assess and score MRI images during unenhanced and contrast-enhanced motion-sensitive sequences for breathing artifacts when Eovist contrast is used versus other contrast agents. Eovist enhanced MRI scans will be compared to previous MRI scans performed with other contrast agents on the same patient that included breath holding sequences. Breathing artifacts on both scans will be evaluated using a respiratory motion score between 1 and 5.

Time frame: 5 years

Secondary Outcomes

Adverse events (including dyspnea)

Number of patients complaining of adverse events after MRI contrast administration.

Time frame: 30 min

Data from ClinicalTrials.gov

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