Efficacy of Intrathecal Administration of Liposomal Amphotericin B in Cryptococcal Meningitis

Hui Bu40 enrolled

Overview

The main purpose of this study is to observe the clinical effect of intrathecal administration of liposomal amphotericin B in Cryptococcal Meningitis without Acquired Immune Deficiency Syndrome (AIDS).

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Cryptococcal Meningitis

Interventions

Liposomal amphotericin BDRUG

Eligibility

Sex: ALLMin age: 14 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Cryptococcus neoformans are found in CSF Exclusion Criteria: * Patients with serious heart, lung, liver and renal insufficiency. * Patients who took broad-spectrum antibiotics and corticosteroids for a long-term. * Patients with AIDS or obvious immunodeficiency. * Patients with long term dialysis or intravenous catheter. * Patients with other brain organic disease such as purulent meningitis, intracranial swelling, etc.

Outcomes

Primary Outcomes

laboratory examination of cerebrospinal fluid

It includes routine test，biochemistry indicators and cytology ，namely white blood cell count per litre， protein（in g/l），glucose（in mmol/l）and chloride（in mmol/l）in cerebrospinal fluid ，an assessment will be assessed every week

Time frame: 2 to 4 weeks

Secondary Outcomes

changes of clinical symptoms

headache duration, duration of fever,presence of cranial nerve damage

Time frame: 2 to 4 weeks

Central Contacts

Hui Bu, MD

CONTACT

86"buhuimy1@163.com

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.