Pre-procedure Planning for Radiofrequency Ablation Using CT or MR/US Fusion

Seoul National University Hospital240 enrolled

Overview

The purpose of this study is to determine whether fusion technique of pre-radiofrequency ablation (RFA) cross-sectional imaging (CT or MR) and real-time ultrasonography would improve feasibility of RFA in patients with liver tumor in comparison with ultrasonography guidance alone.

RFA is one of commonly used local therapies for primary or secondary liver tumors. For successful and safe procedure, safe route of electrode and lesion visibility are essential for RFA, and the conditions are usually evaluated on pre-RFA planning ultrasonography (USG). However, RFA is sometimes aborted due to limited sonic window of various cause and challenging identification of small isoechoic tumors or hepatocellular carcinomas among dysplastic nodules . Therefore, precise targeting and assuring safe route would be of clinical importance. In this preliminary study, investigators attempted to determine US and CT/MR fusion technique would be able to improve RFA feasibility in patients with liver tumors in comparison with conventional US alone technique.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

240

Conditions

Liver Cancer

Interventions

CT/US fusionDEVICE

Fusion of pre-RFA cross-sectional imaging (CT or MRI) and real-time USG using registration function of USG device.

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: all conditions should be satisfied for inclusion. * referred to Radiology in our institution for liver tumor RFA * available pre-RFA liver CT or liver MR imaging within 6 weeks Exclusion Criteria: patients with any of following condition should be excluded. * any contraindication of liver RFA * any patients who received treatment between pre-RFA imaging and planned RFA * patients referred for palliative purpose.

Locations (1)

Seoul National University Hospital

Seoul, South Korea

Outcomes

Primary Outcomes

RFA feasibility rates on planning USG with/without fusion CT/MR and US

comparison of rates of RFA feasibility on conventional planning USG and on fusion planning USG

Time frame: 10 minutes after finishing planning USG

Secondary Outcomes

Rate of tumor visibility on planning USG with/without fusion technique

comparison of tumor visibility (or detection) rates on planning USG on conventional planning USG and fusion planning USG

Time frame: 10 minutes after finishing planning USG

Number of patients with safety access route on planning USG with/without fusion technique

comparison of number of patients with presence/absence of safety access route, and the on two planning USGs

Time frame: 10 minutes after finishing planning USG

Data from ClinicalTrials.gov

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