A single site cross-sectional comparison of paired diagnostic imaging modalities. This study will show the sensitivity and specificity of CEUS in detecting the various types of endoleaks, in comparison to tCTA, following EVAR. It will collect data to allow comparison of diagnostic accuracy across modalities including CDU, CEUS and tCTA. It will collect time taken to perform the various types of scan, to allow healthcare costs to be calculated for each imaging modality.
This study will show the sensitivity and specificity of CEUS in detecting the various types of endoleaks, in comparison to tCTA, following EVAR. It will collect data to allow comparison of diagnostic accuracy across modalities including CDU, CEUS and tCTA. It will collect time taken to perform the various types of scan, to allow healthcare costs to be calculated for each imaging modality. Collected data will be analysed regarding two novel hypothesised methods of using CEUS information: The first is recording temporal delay between contrast in graft and contrast in endoleak to define endoleak type. Potentially this could be used as a faster method of defining endoleak type in a surveillance programme. The second is to identify/refute correlation between CEUS contrast to appear in endoleak vs tCTA contrast to appear in endoleak. If an association can be established, CEUS timings could potentially then be used to time 'standard' CTA phases to improve CTAs diagnostic accuracy.
Study Type
OBSERVATIONAL
Enrollment
30
A multi-phase contrast CT
A ultrasound scan with micro bubble contrast injection
Royal Liverpool Hospital
Liverpool, Merseyside, United Kingdom
Ability to detect type I/III endoleak on CEUS as defined by presence/absence on tCTA
Will be presented as a Sensitivity \& specificity
Time frame: Immediate
Ability to detect type II endoleak on CEUS as defined by presence/absence on tCTA
Will be presented as a Sensitivity \& specificity
Time frame: Immediate
Ability to predict secondary intervention on CEUS as defined by patients proceeding to secondary intervention
Will be presented as a Sensitivity \& specificity
Time frame: Immediate
Confirm / refute association between temporal delay measured on CEUS and endoleak type as defined by tCTA, using the framework of general linear regression.
Temporal delay is the time difference between contrast arriving in the stent graft and contrast arriving in the endoleak on CEUS
Time frame: Immediate
Establish association between "CEUS contrast in endoleak" to "tCTA contrast in endoleak" by general linear regression analysis of timings recorded during CEUS & tCTA.
Time frame: Immediate
Ability to predict secondary intervention of CDU, CEUS and tCTAas defined by patients proceeding to secondary intervention
Will be presented as a Sensitivity \& specificity
Time frame: 6 months
Time taken for CDU, CEUS & tCTA scans to be performed as measured by observer.
Used to calculate total resource utilisation by individual scan types.
Time frame: Immediate
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.