This study will compare the test performance characteristics of visual inspection with acetic acid (VIA), Xpert HPV, and OncoE6 in HIV-infected women, to inform the possible inclusion of these molecular tests in future cervical cancer screening
This is a cross-sectional study taking place at cervical cancer prevention clinics in Lusaka, Zambia to determine the test performance characteristics (sensitivity, specificity, positive predictive value, and negative predictive value) of (1) visual inspection with acetic acid, (2) Xpert HPV, and (3) OncoE6 for the detection of CIN2+ among HIV-infected women. All cervical screening tests will be evaluated against a gold standard of histopathology obtained from cervical biopsies.
Study Type
OBSERVATIONAL
Enrollment
200
Adult Infectious Disease Centre at the University Teaching Hospital
Lusaka, Zambia
Proportion of VIA-, Xpert HPV-, and OncoE6-positive results that are correctly identified
True positive rate (i.e., sensitivity) for CIN2+
Time frame: once, at the enrollment visit
Proportion of VIA-, Xpert HPV-, and OncoE6-negative results that are correctly identified
True negative rate (i.e., specificity) for CIN2+
Time frame: once, at the enrollment visit
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