Incidence of Urinary Retention in Patients Undergoing Unilateral Total Knee Arthroplasty- Comparison Between Continuous Epidural Analgesia and Single Shot Femoral Nerve Block- a Randomized Controlled Study (UriKANE)

Aga Khan University60 enrolled

Overview

This study aims to compare the incidence of urinary retention and requirement of bladder catheterization in patients undergoing total knee arthroplasty while receiving either continuous epidural analgesia or single shot femoral nerve block.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Masking

NONE

Enrollment

Conditions

Acute Pain Urinary Retention Post Operative Pain

Interventions

Femoral Nerve BlockPROCEDURE

For patients in Femoral nerve Block Group (Group F), ultrasound guided Femoral nerve block was performed using 0.375% bupivacaine, 20 ml for femoral nerve

EpiduralPROCEDURE

Patients in Epidural Group (Group E) were turned in lateral position for epidural catheter placement in lumbar region. Epidural was loaded with 0.25% bupivacaine and infusion of M2 (Bupivacaine 0.1% + Fentanyl 2mcg/ml) was started at 8 - 12 ml per hour.

Eligibility

Sex: ALLMin age: 30 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * ASA Physical status I, II \& III * Male and Female Patients age between between 30 and 70 years * Unilateral Total Knee Arthroplasty Exclusion Criteria: * Patient Refusal * Allergy to local anesthetics, paracetamol or other study drugs * History of opioid dependence * Contraindications to spinal/epidural anesthesia and femoral nerve block (coagulation defects, infection at puncture site etc.) * Inability to use patient-controlled analgesia (IV PCIA) (as assessed at the time of informed consent) * History of urinary retention, neurogenic bladder, or any urologic problem

Locations (1)

Aga Khan University

Karachi, Pakistan

Outcomes

Primary Outcomes

Incidence of urinary retention

To compare the incidence of urinary retention in patients undergoing unilateral Total Knee Arthroplasty receiving continuous epidural analgesia vs. single shot Femoral Nerve Block.

Time frame: 24 Hours

Secondary Outcomes

Mean post-operative nausea and vomiting scores

To compare the mean post-operative nausea and vomiting scores between the two groups at 0, 1, 12, 24 \& 48 hours postoperatively.

Time frame: up to 48 hours

Mean post-operative sedation scores

To compare the mean post-operative sedation scores between the two groups at 0, 1, 12, 24 \& 48 hours postoperatively.

Time frame: up to 48 hours

Mean post-operative pain scores

To compare the mean post-operative pain scores between the two groups at 0, 1, 12, 24 \& 48 hours postoperatively.

Time frame: up to 48 hours

Surgical outcomes - maximal knee flexion

To compare surgical outcomes like maximal knee flexion at 24 \& 48 hours between the two groups

Time frame: up to 48 hours

Surgical outcomes - duration of post-operative hospital stay

To compare surgical outcomes like duration of post-operative hospital stay between the two groups

Time frame: up to 48 hours

Surgical outcomes - mobilization out of bed

To compare surgical outcomes like time taken to mobilize out of bed between the two groups

Time frame: up to 48 hours

Data from ClinicalTrials.gov

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