A Phase 2 Trial Testing ZP1848 in Patients With SBS

Inclusion Criteria: * Following receipt of verbal and written information about the trial, the patient must provide signed informed consent before any trial related activity is carried out. * Age ≥ 18 years and ≤ 90 years * Stable SBS patients with intestinal insufficiency or failure, where the last surgical resection of gut tissue was performed at least 1 year ago * A stable PS volume ( \< 25% change in volume or energy content) for four weeks prior to randomization for patients requiring PS * Wet weight of fecal excretion ≥ 1500 g/day demonstrated during a hospital stay prior to screening or during at least one day of the first baseline balance study. * Stable body weight (\<5% weight deviance in the three months prior to screening) Exclusion Criteria: * Patients with known or suspected intestinal strictures of clinical relevance as judged by the Investigator * Active inflammatory bowel disease (IBD) or fistula during the screening period as judged by conventional means of the Investigator. * Crohn's disease patients not being in clinical remission for the last 12 weeks prior to randomization * Cardiac disease defined as: Decompensated heart failure (NYHA class III-IV) and/or diagnosis of unstable angina pectoris and/or myocardial infarction within the last 6 months prior to screening * History of cancer (except resected cutaneous basal or squamous cell carcinoma and except in situ cervical cancer) unless it can be documented that the patient has been in a disease-free state for at least 5 years (except colon cancer: patients with a history of colon cancer generally have to be excluded) * eGFR (by the MDRD formula) \<30 mL/min/1.73 m2 * Clinically meaningful renal disease as judged by the Investigator