A Study to Investigate the Safety, Tolerability and Pharmacokinetics of ABY-035

Inclusion Criteria: Part A, Part B * Males or females between 18 and 65 years of age * Body mass index (BMI) between 18.0 kg/m2 and 32.0 kg/m2, inclusive. maximum body weight of 120 kg * In good health, as determined by medical history, physical examination, vital signs assessment, 12 lead electrocardiogram (ECG) and clinical laboratory evaluations. * Subjects will have given their written informed consent to participate in the study In addition for Part C and D * Males or females between 18 and 65 years of age * Body mass index (BMI) between 18.0 kg/m2 and 39.9 kg/m2, inclusive. Minimum body weight of 45 kg * Part C: Patients must have had a diagnosis of moderate to severe plaque type psoriasis at least 6 months prior to administration of the study drug without a documented flare within 30 days prior to Screening. Patients with concurrent psoriatic arthritis may be enrolled. * Part D: Patients must have had a diagnosis of plaque type psoriasis (mild, moderate or severe) at least 6 months prior to administration of the study drug without a documented flare within 30 days prior to Screening. Patients with concurrent psoriatic arthritis may be enrolled. * Part C: Have plaque type psoriasis covering at least 10% of total body surface area (BSA) at Screening and at Baseline (Day 1) and have a PASI score of 12 or greater at Screening and at Baseline (Day 1). * Part D: Have at least one psoriatic lesion Exclusion criteria: Part A, Part B, Part C and Part D * Subjects who have any clinically significant medical history, as determined by the investigator * Subjects who smoke more than 15 cigarettes, or equivalent, per day * Alcohol and/or drug abuse * Positive for HIV, Hepatitis B, Hepatitis C, or tuberculosis * Subjects who have received a live vaccination within the 3 months prior to Screening * Subjects who are pregnant or lactating * Subjects who do not agree to use appropriate contraception * Subjects who have a history of anaphylaxis, drug allergy or clinically significant allergic condition (excluding non active hayfever) * Participation in another clinical trial * Subjects who, in the opinion of the investigator, should not participate in this study In addition for Part C and D * Patients who currently have non plaque forms of psoriasis (eg, erythrodermic, guttate, or pustular) * Patients who have current drug induced psoriasis * Have any history of any use of or have participated in clinical trials for any therapeutic agent directly targeted to any IL 17 cytokine or receptor * Have received phototherapy within 4 weeks prior to Day 1 * Patients who have received systemic medications or treatments that could affect psoriasis or PASI evaluation (including, but not limited to, oral or injectable corticosteroids, retinoids, 1,25 dihydroxy vitamin D3 and analogues, fumaric acid esters, psoralens, anti TNF (tumour necrosis factor) biologics, anti IL 12/23 biologics, or herbal treatments), within 5 half lives prior to Day 1 (4 weeks for oral anti psoriatics, 12 weeks for psoralens and PUVA (oral psoralen with ultraviolet A), and 24 weeks for biologics) * Patients who have used topical medications and treatments that could affect psoriasis or PASI evaluation (eg, corticosteroids, coal tar, anthralin, calcipotriene, topical vitamin D derivatives, retinoids, tazarotene, methoxsalen, and trimethyl psoralens) within 2 weeks of administration of IMP (Investigational Medicinal Product) * Patients who have used any systemic immunosuppressants (eg, methotrexate, azathioprine, cyclosporine, 6 thioguanine, mercaptopurine, mycophenolate mofetil, hydroxyurea, or tacrolimus) within 8 weeks of administration of IMP (or 5 half lives, whichever is longer).