Perioperative Endothelial Dysfunction in Patients Undergoing Minor Abdominal Surgery

Zealand University Hospital60 enrolled

Overview

This study on minor surgery serves to explore whether a dose-response relationship exists between surgical stress and endothelial dysfunction in the early postoperative period. The aim of this explorative and observational clinical study is to closely examine the endothelial function and its dynamics in the early postoperative period after minor surgery (lap. inguinal hernia repair). The endothelial function will be assessed indirectly by EndoPat and plasma biomarkers of nitric oxide bioavailability. The study will contribute to the understanding of perioperative myocardial injury, which is crucial for optimized treatment of patients at risk of cardiovascular complications.

The investigators will include 60 patients undergoing elective inguinal hernia repair. The endothelial function will be measured before surgery and 4 hours after surgery with the EndoPat system. The NO-bioavailibility will be measured by plasma l-arginine, plasma ADMA and plasma biopterins.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Myocardial Injury

Interventions

Elective SurgeryPROCEDURE

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients scheduled for a laparoscopic inguinal hernia repair * Patients ≥ 18 years old Exclusion Criteria: * Not capable of giving informed consent after oral and written information * Previously included in the trial - Surgery within 7 days of the trial

Outcomes

Primary Outcomes

Change in endothelial function assessed by the EndoPat system

Time frame: At baseline and 4 hours postoperatively

Secondary Outcomes

Change in biomarkers of endothelial function: plasma arginine, plasma ADMA, plasma biopterins