The Effect of Pregabalin on the Spinal Anesthesia

Kyungpook National University Hospital44 enrolled

Overview

Pregabalin, an anticonvulsant is widely used for treatment of neuropathic pain. Recently, it was reported that premedication of pregabalin before general anesthesia is effective to reduce postoperative pain. Up to date, there is no study about the effect of premedication of pregabalin on the spinal anesthesia. Therefore, in this study, investigators investigate the effect of premedication of pregabalin on the spinal anesthesia.

In this study, investigators investigate the effect of premedication of pregabaline 150 mg on the spinal anesthesia. Two hours before spinal anesthesia, placebo pill was administered to patients in the group C and pregabalin 150 mg was administered to patients in the group P, respectively. Time for the onset of blockade, cephalad level of analgesia and duration of analgesia were measured.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Masking

QUADRUPLE

Enrollment

Conditions

Block

Interventions

PlaceboDRUG

PregabalinDRUG

Eligibility

Sex: ALLMin age: 19 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients of American Society of Anaesthesiologists Grades I and II Exclusion Criteria: * Patients with infection at the puncture site, coagulopathy, having true hypersensitivity to drugs used, diabetes and hypertension, psychiatric and neurological diseases

Locations (1)

Kyungpook National University Hospital

Daegu, South Korea

Outcomes

Primary Outcomes

Duration of spinal anesthesia

Duration of spinal anesthesia was measured 24 after spinal anesthesia

Time frame: 24 hours after spinal anesthesia

Data from ClinicalTrials.gov

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