Different Regulation of Immune Cells in Patients With Preeclampsia

University Medical Center Groningen30 enrolled

Overview

Adaptation of the maternal immune system to accommodate the semi-allogeneic fetus is necessary for pregnancy success. Dysregulation of this immune adaptation is implicated in reproductive disorders as infertility, recurrent miscarriage, fetal growth restriction, and preeclampsia. The mechanisms being responsible for fetal tolerance are not known. Several T cell subsets have been implicated in fetal tolerance. The effects of preeclampsia on memory cells are not known. The main objective of this study is to analyze the effect of preeclampsia on levels of immune cells.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Preeclampsia Pregnancy

Interventions

Blood withdrawalPROCEDURE

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 40 Years

Medical Language ↔ Plain English

Inclusion Criteria: * healthy * written informed consent * 18-40 years Exclusion Criteria: * smoking * immune related disorders (other than preeclampsia) * fever / illness within the last month * infertility * body mass index \<18 or \>30

Outcomes

Primary Outcomes

Cell levels

Time frame: 1 year

Data from ClinicalTrials.gov

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