Goal of this study is to measure serum cholinesterase activity in patients with traumatic and/or burns injury admitted to the emergency room by using point-of- care-test system (POCT). Serum cholinesterase activity, measured using POCT system, might play an important role in the early diagnosis and prediction of patient outcome in trauma-induced systemic inflammation.
Study Type
OBSERVATIONAL
Enrollment
85
Department of Anaesthesia, Intensive Care Medicine and Pain Therapy, BG Trauma Center Ludwigshafen
Ludwigshafen am Rhein, Rhineland-Palatinate, Germany
Early diagnosis of the systemic inflammation by using the serum cholinesterase activity measurement
By using Point-of-care measurement of serum cholinesterase activity (U/l) and by observing a change in the enzyme activity over time (reduction of serum cholinesterase activity within the first 6 hours after traumatic injury) would allow an additional tool in early diagnosis and treatment of systemic inflammation.
Time frame: after completed patient recruitment, 1 year
correlation of the cholinesterase activity and the trauma/disease severity scores
To evaluate the correlation of the serum cholinesterase activity change with the trauma severity, the obtained serum cholinesterase activities (U/l) will be compared to the trauma severity scores (ISS, %TBSA).
Time frame: after completed patient recruitment, 1 year
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