The aim of this study is to assess the efficacy and safety of melatonin in control of blood sugar in patients with type 2 diabetes mellitus (DM).
Diabetes mellitus (DM) is a major public health problem with increasing worldwide incidence. The main causes for increase in incidence of DM are inactivity, obesity and changes of dietary habits. Investigators think that the changes in the awake-sleep cycle may also contribute to higher incidence of DM in recent years. Melatonin is an important component of the circadian system. Numerous experimental studies have demonstrated that melatonin has many beneficial actions.Melatonin is a potent antioxidant, reduces inflammatory process, lowers blood pressure, improve lipid profiles. Collectively, these data suggest that melatonin may be useful in control of blood sugar in patients with DM. The aim of this study is to assess the efficacy of melatonin in control of blood sugar in patients with type 2 DM.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
60
Shahid Motahhari Clinic, Shiraz University of Medical Sciences
Shiraz, Fars, Iran
Fasting blood sugar (FBS)
Time frame: 3 months
HbA1c
Time frame: 3 months
Serum Insulin
Time frame: 3 months
Weight (Body mass index)
Time frame: 3 months
Waist circumference
Time frame: 3 months
Serum aminotransferases
Time frame: 3 months
Number of patients with adverse events
Time frame: 3 months
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