A Study of ALKS 3831 in Adults With Schizophrenia (The ENLIGHTEN-2 Study)

Inclusion Criteria: * Subject has a body mass index (BMI) of 18.0-30.0 kg/m\^2, inclusive, at Visit 1 and Visit 2 * Subject meets the DSM-5 criteria for a primary diagnosis of schizophrenia * Subject is appropriate for outpatient treatment; has no hospitalizations for acute exacerbations of schizophrenia within 6 months before Visit 1 * Subject has maintained a stable body weight (change \</= 5%) for at least 3 months prior to Visit 1 based on self-report * Additional criteria may apply Exclusion Criteria: * Subject has any of the following psychiatric conditions per DSM-5 criteria: * Diagnosis of schizoaffective disorder or bipolar I or II disorder, or current, untreated or unstable major depressive disorder * Clinically significant cognitive difficulties present within the past 2 years that could interfere with participation in the study * Drug-induced or toxic psychosis * Any other psychiatric condition that could interfere with participation in the study * Subject poses a current suicide risk at Visit 1 or Visit 2 in the opinion of the investigator * Subject has inflammatory bowel disease or any other gastrointestinal disorder associated with weight loss, anorexia nervosa, or binge eating disorder * Additional criteria may apply