Expression of EPK in Recurrent Miscarriage

Assiut University39 enrolled

Overview

The present study is based on hypotheses that some as yet unknown genetic factors may result in recurrent miscarriage (RM). Consequently, the main aim of this study was to gain new information about the underlying genetic causes of RM in the Egyptian population and to investigate the expression of ERK and p-ERK protein in human placenta and their corresponding tissue, to assess the significance of MAPK signal pathway in progression of recurrent miscarriage and PI3K-Akt Pathway.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Recurrent Miscarriage

Interventions

Investigate the MAP kinase signaling pathways through ERK and p-ERK proteinsOTHER

Eligibility

Sex: FEMALEMin age: 20 YearsMax age: 40 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Gestational age less than 12 weeks. 2. no uterine abnormalities (examined by ultrasonography or hysterosonogram) 3. previous history of RM, defined as two or more consecutive miscarriages Exclusion Criteria: 1. Gestational age 12 weeks or more. 2. Endocrine etiology like (thyroid dysfunction, and uncontrolled diabetes mellitus). 3. Antiphospholipid syndrome, inherited thrombophilias, alloimmune causes. 4. Uterine anatomic anomalies

Locations (1)

Ahmed Abbas

Assiut, Cairo Governorate, Egypt

Outcomes

Primary Outcomes

The levels of ERK and AKT in placenta

Time frame: 48 hours

Data from ClinicalTrials.gov

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