Fecal microbiota transplantation (FMT) is recommended in the treatment of recurrent Clostridium difficile infection (CDI). The principle is to administer a fecal suspension of a healthy subject (donor) in the digestive tract of a patient with an CDI (receiver). Donors are being clinical and laboratory screening to reduce the likelihood of pathogens transmission (infectious and other). Cytomegalovirus (CMV) is part of the examinations requested by the Agence national de sécurité du médicament et des produits de santé in the context of clinical research. A sero-matching between donor and recipient CMV is requested. This recommendation eliminates many potential donors to a recipient. To date, the frequency detection level of CMV in stool in healthy volunteers with documented positive CMV serology is not known. In addition, CMV transmission risk via the stool is not established. This study aims to determine the detection frequency of CMV in healthy volunteers stool samples selected as potential donors for a FMT and having a positive CMV serology documented
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
500
Blood sample at Day 1 and blood and stool sample at the next visit
Centre de biologie pathologie / Laboratoire de virologie
Lille, France
Cic 1403-Crb Inserm-Chu
Lille, France
Service des Maladies Infectieuses
Lille, France
Cic - Inserm - 1435
Limoges, France
Service de Bactériologie-Virologie-Hygiène/CNR des Cytomégalovirus
Limoges, France
Detection frequency of CMV
Detection frequency of CMV in healthy volunteers stool samples with the selection criteria for the gift of fecal microbiota and having a CMV positive serology
Time frame: 30 days
Presence of CMV in the stool and in blood.
Evaluation of the link between the presence of CMV in the stool and the detection of CMV viral load in whole blood.
Time frame: At day 30
Infectivity of CMV present in faecal
Evaluation of the infectivity of CMV present in faecal
Time frame: At day 30
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