Ketone Production With Acute Caffeine Intake

Université de Sherbrooke10 enrolled

Overview

Evaluate the effect of a caffeine supplement on the stimulation of lipolysis and the production of ketones in healthy adults (N=10).

The aim of the study is to evaluate the effect of a caffeine supplement on the stimulation of lipolysis and the production of ketones in healthy adults (N=10). Two different doses of caffeine (2.5 mg/kg of BW and 5 mg/kg of BW) are compared. All the participants have to follow three sequential visits of four hours each, which included a breakfast with one of the doses (2.5 or 5 mg/kg) of the caffeine supplement or without any supplement (baseline) and repeated blood sampling in order to evaluate ketone concentrations.

Study Type

INTERVENTIONAL

Allocation

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Healthy Adults

Interventions

ControlDIETARY_SUPPLEMENT

4-hour visit with no caffeine is given during a standardize breakfast follow by repeated blood sampling.

Caffeine low doseDIETARY_SUPPLEMENT

4-hour visit with a dose of 2.5 mg/kg of caffeine is given during a standardize breakfast follow by repeated blood sampling.

Caffeine high doseDIETARY_SUPPLEMENT

4-hour visit with a dose of 5 mg/kg of caffeine is given during a standardize breakfast follow by repeated blood sampling.

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy adults * 18 years old and over Exclusion Criteria: * Drinking more than 300 mg of caffeine per day * Diabetes or prediabetes * Abnormal liver and kidney function * Uncontrolled dyslipidemia, blood pressure * Use of drugs known to influence the metabolism of lipids and carbohydrates (steroid, beta-blockers, diuretics, insulin sensitizer, etc.) * Severe inflammation or infection * Pregnancy * Smoking

Locations (1)

Research Centre on Aging (CSSS-IUGS - CIUSSS de l'Estrie - CHUS)

Sherbrooke, Quebec, Canada

Outcomes

Primary Outcomes

Plasma Acetoacetate Concentrations

Plasma acetoacetate (µmol/L) measured over a 4 hour period.

Time frame: 4 hours

Plasma Beta-hydroxybutyrate Concentrations

Plasma beta-hydroxybutyrate (µmol/L) measured over a 4 hour period.

Time frame: 4 hours

Secondary Outcomes

Plasma Glucose Concentrations

Plasma glucose (mmol/L) measured over a 4 hour period.

Time frame: 4 hours

Plasma Cholesterol Concentrations

Plasma cholesterol (mmol/L) measured over a 4 hour period.

Time frame: 4 hours

Plasma Triglyceride Concentrations

Plasma triglycerides (mmol/L) measured over a 4 hour period.

Time frame: 4 hours

Data from ClinicalTrials.gov

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