The aim of this prospective non-interventional neuropsychological one visit study involving functional MRI (fMRI) is to ascertain emotional processing in patients with Multiple Sclerosis (MS) or Clinically Isolated Syndrome (CIS) compared to healthy control subjects. In different experiments, the modulation of cognitive and motor responses by visual emotional information and the ability to discriminate visual emotional stimuli will be tested using experimental behavioral paradigms. Furthermore, functional connectivity and - using fMRI - activations of brain regions known to be involved with emotional processing will be evaluated.
Study Type
OBSERVATIONAL
Enrollment
60
Charité Unversitätsmedizin Berlin; NeuroCure Clinical Research Center NCRC
Berlin, Germany
Emotional modulation of motor response time
Δ (\[Response time following neutral stimuli\] - \[Response time following emotional stimuli\])
Time frame: 1 day
Emotional memory performance
%-correct recognized emotional and neutral stimuli
Time frame: 1 day
Emotional experience
Subjective valence and arousal ratings of emotional and neutral stimuli
Time frame: 1 day
BOLD-fMRI brain responses during emotional processing
Time frame: 1 day
Expanded Disability Status Scale (EDSS)
Time frame: 1 day
Multiple Sclerosis Functional Composite (MSFC)
Time frame: 1 day
Short Form Health Survey (SF-36)
Time frame: 1 day
Satisfaction With Life Scale (SWLS)
Time frame: 1 day
Paced Auditory Serial Addition Test (PASAT)
Time frame: 1 day
Serial Reaction Time (SRT) Task
Time frame: 1 day
Symbol Digit Modalities Test (SDMT)
Time frame: 1 day
Beck depression inventory BDI-2
Time frame: 1 day
Positive and Negative Affect Schedule (PANAS)
Time frame: 1 day
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