Safety, PK, and Efficacy of Omecamtiv Mecarbil in Japanese Subjects With Heart Failure With Reduced Ejection Fraction

Inclusion Criteria: * Japanese male or female ≥ 20 years and ≤ 85 years of age * History of chronic stable heart failure (HF) with reduced ejection fraction, defined as requiring treatment for HF for a minimum of 4 weeks prior to screening * Treated for HF with optimal pharmacological therapy * Left ventricular ejection fraction ≤ 40% at screening Exclusion Criteria: * Severe uncorrected valvular heart disease * Hypertrophic obstructive cardiomyopathy, active myocarditis, constrictive pericarditis, or clinically significant congenital heart disease * Acute myocardial infarction, unstable angina, or persistent angina at rest within 30 days prior to randomization * Systolic blood pressure (BP) \> 160 mmHg or \< 90 mmHg, or diastolic BP \> 90 mmHg, or heart rate (HR) \> 110 beats per minute (bpm) or HR \< 50 bpm * Estimated glomerular filtration rate (eGFR) \< 30 mL/min/1.73 m\^2 * Total bilirubin (TBL) ≥ 2x upper limit of normal (ULN), or alanine aminotransferase (ALT) or aspartate aminotransferase (AST) ≥ 3x ULN Other Exclusion Criteria may apply.