Administration of Oral Extended Release Minocycline for Assessment of Skin and Plasma Concentrations of Minocycline

Inclusion Criteria: * Otherwise healthy male and female subjects 14 to 40 years of age * Moderate to severe inflammatory facial acne vulgaris (EGSA score of 3-5) * Subjects not using oral or topical antibiotic products for at least 30 days prior to study entry and willing to refrain from use of oral and topical antibiotics for the duration of study participation * Subjects not currently using and willing to refrain from use of other topical acne products for the duration of study participation Exclusion Criteria: * Mild, non-inflammatory or nodular acne vulgaris * Have current or previous skin cancer * Have a history of skin disease or presence of skin condition the PI believes would interfere with the study * Females who report that they are pregnant, planning a pregnancy during the study period or breastfeeding * Have conditions or factors that the PI believes may affect the response of the skin or the interpretation of the results * Participation in any clinical study within the previous 30 days or plan concurrent participation in other studies