Experimental Biomarker Study for Pain Thresholds

Inclusion Criteria include: 1. Signed informed consent obtained. 2. Males aged 18 to 45, inclusive. 3. Body weight ranging from 50 to 100 kg and BMI ranging from 18 to 32 (kg/m2), inclusive. 4. Healthy and free of significant abnormal findings as determined by medical history, physical examination, clinical laboratory values, vital signs, and ECG. Exclusion Criteria include: 1. Current or recent (within 5 years) history of drug or alcohol abuse. 2. History or any current conditions that might interfere with drug absorption, distribution, metabolism or excretion. 3. Any history of frequent nausea or emesis regardless of etiology. 4. Any history of allergic-type reactions to sulfonamides, or any experience of asthma, urticarial, or other allergic-type reactions after taking aspirin or other NSAIDS. 5. Subjects who do not develop erythema at the maximum dose of the UVB source (MED determination for UVB model) will be excluded from the study. Other protocol-specific inclusion/exclusion criteria may apply.