Immunotherapy in Intractable Cryptogenic Epilepsy Patients With Autoimmune Antibody

Inclusion Criteria: * A diagnosis of cryptogenic epilepsy according to the International League Against Epilepsy's Classification of Epilepsy. * Intractable epilepsy: Complete seizure control is not achieved with trials of two appropriate antiepileptic drugs * At least 1 seizure within the past 8 weeks * Presence of autoimmune antibody (NMDAR, LGI1, CASPR2, AMPA1, AMPA2, GABAB-R, anti-Hu, -Yo, -Ri, -Ma2, -CV2/CRMP5, -amphiphysin, GAD) in serum or cerebrospinal fluid * Written informed consent signed by the subject or legal guardian prior to entering the study Exclusion Criteria: * Clinical evidence of autoimmune encephalitis such as autoimmune limbic encephalitis * History of severe head trauma * Presence of structural abnormality which is thought to be epileptogenic in brain MRI * Epilepsy of predominantly genetic or presumed genetic origin * An active CNS infection, demyelinating disease, degenerative neurologic disease or any CNS disease deemed to be progressive during the course of the study that may confound the interpretation of the study results History of immunotherapy * A history of nonepileptic or psychogenic seizures within past 1 year * Any clinically significant laboratory abnormality that in the opinion of the Investigator would exclude the subject from the study * Any clinically significant psychiatric illness, psychological, or behavioral problems that, in the opinion of the Investigator, would interfere with the subject's ability to participate in the study * Recent (within 4 weeks) change or dose adjustment of anti-epileptic drug (1 to 2 doses of rescue benzodiazepine is permitted) * Refuse to participate in the study