Diaphragmatic Echography in Critically Ill patientS

Università degli Studi di Ferrara44 enrolled

Overview

Acute respiratory failure (ARF) is characterised by a discrepancy between load imposed on respiratory muscles and their capacity. Recently, diaphragmatic ultrasonography has been introduced in the clinical practice to evaluate diaphragmatic function. In particular, the investigators will focus on Diaphragmatic Displacement measured by M-mode ultrasonography. The aim of this study was to compare the diaphragmatic displacement with traditional weaning parameters in potentially ready to be extubated patients undergoing a spontaneous breathing trial (SBT).

Study Type

OBSERVATIONAL

Enrollment

Conditions

Respiratory Failure

Interventions

UltrasonographyDEVICE

Ultrasonographic assessment of the diaphragm function

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * mechanically ventilated since more than 24 hours * clinical improvement of the underlying acute cause of the respiratory failure * adequate cough reflex * absence of excessive and/or purulent tracheobronchial secretion * stable cardiovascular status * stable metabolic status * adequate pulmonary function * adequate mentation Exclusion Criteria: * age \<18 years * pregnancy * presence of thoracostomy, pneumothorax or pneumomediastinum * presence of flail chest or rib fractures * neuromuscular disease * use of muscle-paralyzing agents within 48 hours before the study * history or new detection of paralysis or paradoxical movement of a single hemi-diaphragm on diaphragm ultrasonography

Locations (1)

Azienda Ospedaliero Universitaria Sant'Anna

Ferrara, Italy

Outcomes

Primary Outcomes

Weaning success

A successful weaning attempt was registered when patients were extubated and breathed spontaneously for more than 48 hours. The reinstitution of mechanical ventilation at the end of spontaneous breathing trial, reintubation within 48 hours or non-invasive ventilation (NIV) support after extubation defined a failed weaning attempt.

Time frame: within the first 48 hours after the spontaneous breathing trial

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.