A Study of IBRF Disorders of Consciousness Advanced Care/MultiModal Care Protocol in Severe Disorders of Consciousness

Inclusion Criteria: * Age 18 years to ≤ 65 years * GCS rating of 3 to 9 (severe impairment) * Evidence of an acquired brain injury that severely suppresses consciousness * Coma, vegetative state, or minimally conscious state based on definitions of the Mohonk Report * If polytrauma, patient is medically stable Exclusion Criteria: * GCS of 10 or greater (moderate to mild impairment) * Tracheostomies requiring ventilator support * Medical condition that precludes objective assessment (e.g., concurrent Guillain-Barre or other severe peripheral neuropathy, severe critical illness myopathy/polyneuropathy) * Onset of injury greater than 12 months post hypoxic ischemic injury (HII) * Onset of injury greater than 24 months post traumatic brain injury (TBI) * Emergence during the screening period * Terminal illnesses, existing severe neuro-developmental disorders, existing chronic degenerative neurological conditions, prior moderate-to-severe TBI, or any stroke syndrome other than transient ischemic attack (TIA), or a prior seizure disorder * Patients with an uncontrolled seizure disorder, or seizure disorder can only be controlled with medication that is contra-indicated (e.g., dilantin or phenobarbitol), * In the opinion of the attending physician, the patient presents with a cardiac condition that would place them at unacceptable risk, or has a documented ejection fraction (EF) \<25%