Long term maintenance of weight loss is generally poor, which is at least partly due to increased feelings of hunger associated with restricting what can be eaten. Intermittent severe energy restriction is a novel dietary strategy that requires individuals to consume a very-low energy diet for 1-4 days per week, allowing normal feeding patterns to be adopted on the other days in the week. However, the effect of a consuming a very-low energy diet on appetite regulation, which might represent a key marker of long-term adherence to dieting, has not been determined. This study aimed to assess the effects of severely restricting energy intake for 24 h on markers of appetite regulation, energy balance and metabolism compared to an adequate energy trial.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
18
Ad-libitum energy intake
Measured at laboratory-based meals and weight food records
Time frame: 48 hours
Subjective appetite
Measured using visual analogue scales
Time frame: 48 hours
Plasma acylated Ghrelin
Measured using ELISA from venous blood samples
Time frame: 24 hours
Plasma active glugagon-like peptide 1
Measured using ELISA from venous blood samples
Time frame: 24 hours
Plasma insulin
Measured using ELISA from venous blood samples
Time frame: 24 hours
Plasma glucose
Measured using colorimetric assay from venous blood samples
Time frame: 24 hours
Plasma Non-esterified Fatty acids
Measured using colorimetric from venous blood samples
Time frame: 24 hours
Energy expenditure
Measured under resting conditions using indirect calorimetry
Time frame: 24 hours
Fat oxidation
Measured under resting conditions using indirect calorimetry
Time frame: 24 hours
carbohydrate oxidation
Measured under resting conditions using indirect calorimetry
Time frame: 24 hors
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