To develop and validate the noninvasive measurement of MBF and MFR by using dynamic imaging with a CZT camera, and evaluate the diagnostic and prognostic implications in various heart disease.
Absolute myocardial blood flow (MBF) and myocardial flow reserve (MFR) provide incremental diagnostic and prognostic information over relative perfusion alone. Recent development of dedicated cardiac SPECT cameras with better sensitivity and temporal resolution make dynamic SPECT imaging more practical. The potential roles of myocardial perfusion in subjects with cardiovascular risks and heart failure warrant further investigations. The present project aims to develop and validate the noninvasive measurement of MBF and MFR by using dynamic imaging with a CZT camera, and evaluate the diagnostic and prognostic implications.
Study Type
OBSERVATIONAL
Enrollment
234
Thallium (Tl-201) myocardial single photon emission tomography, dynamic imaging
Far Eastern Memorial Hospital
New Taipei City, Taiwan
Coronary artery disease (CAD) diagnosis
CAD defined as more than 50% stenosis in any vessel by coronary angiography or computed tomography.
Time frame: 12 months after the index MPI
MACE (major adverse cardiac events)
revascularization, acute myocardial infarction, hospitalization for heart failure, cardiac death, non-cardiac death
Time frame: 5 years after the index MPI
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