Hemodialysis-based Interventions to Preserve Cognitive Function

Johns Hopkins Bloomberg School of Public Health24 enrolled

Overview

This will be a pilot, single center, randomized, controlled trial to slow cognitive decline in adults undergoing hemodialysis (HD). The investigators will test two interventions (cognitive training and exercise training) against the standard of care.

This will be a pilot, single center, randomized, controlled trial to slow cognitive decline in adults undergoing hemodialysis (HD). The investigators primary objective is to demonstrate feasibility for the interventions (cognitive training and exercise training) in Aim 1. The investigators will formally test whether whether cognitive training (tablet-based brain games) and exercise training (stationary foot pedal) administered during HD slow cognitive decline as well as improve secondary outcomes (physical function, frailty, and health-related quality of life (HRQOL) as part of Aim 2. The investigators will compare these two interventions against the standard of care. Pre- and post-intervention assessments will be conducted at the dialysis unit by a study coordinator and by research assistants. Participants will be followed for 6 months to assess cognitive decline.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Enrollment

Conditions

Kidney Failure, Chronic

Interventions

cognitive trainingOTHER

The investigators will provide participants with tablets to play brain games through Lumosity.

exercise trainingOTHER

The investigators will provide participants with foot peddlers.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Men and women with end stage renal disease and receiving hemodialysis at the DaVita Dialysis Centers located at 409 N. Caroline St., Baltimore, MD will be approached by our study coordinator to determine eligibility. * Must be at least 18 years or older at enrollment * Must be English speaking * Must be willing to participate in research and able to give informed consent Exclusion Criteria: * Chronic lung disease requiring oxygen * Cerebrovascular disease * Musculoskeletal conditions that limit mobility * Lower or upper extremity amputation * Orthopedic disorders exacerbated by physical activity * Decreased mental capacity * Dementia (diagnosed)

Locations (1)

Bond St DaVita Dialysis Center

Baltimore, Maryland, United States

Outcomes

Primary Outcomes

Cognitive function measured using the Modified Mini Mental Status

Cognitive decline assessed as both the change in Modified Mini Mental Status and Trail making Test A and B scores as well as 10% decline in these measures of cognitive function