Astigmatic Vector Analysis of Posterior Cornea - a Comparison Among Healthy, Forme Fruste and Overt Keratoconus Corneas

University of Sao Paulo698 enrolled

Overview

The main purpose of this study is to determine new diagnostic criteria for an eye disease called keratoconus.

Eyes of patients who distinctly present signs of keratoconus, for both eyes, at corneal tomography (an exam commonly used in such cases), and those who present such signs in only one eye were compared to eyes of unaffected patients. Several characteristics of anterior and posterior corneal astigmatism (special emphasis was given to the latter) were collectively assessed among all patients by a method referred to as vectorial analysis. Statistical tests were then performed, in an attempt to highlight differences among those three groups of patients and, eventually, define new diagnostic criteria.

Study Type

OBSERVATIONAL

Enrollment

698

Conditions

Keratoconus

Interventions

Analysis of anterior and posterior corneal surfacesOTHER

Corneal data obtained from a Scheimpflug-based topographer were converted to astigmatic vectors in accordance to the method proposed by Thibos

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * Good-quality Scheimpflug scans (approved by the device in the ''Examination Quality Specification''). Exclusion Criteria: * Previous eye surgery or trauma, and any sort of corneal scarring that might interfere with keratometric data acquisition.

Locations (1)

Clínica Oftalmológica do Hospital de Clínicas - FMUSP

São Paulo, São Paulo, Brazil

Outcomes

Primary Outcomes

Astigmatism corneal vectors (based on keratometric readings at the three millimeter optical zones for both corneal surfaces).

Corneal tomography at an Scheimpflug-based tomographer

Time frame: Through study completion, an average of 6 months.

Data from ClinicalTrials.gov

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