Unloading Induced Effects on Local Glucose Uptake Into m. Soleus

Inclusion Criteria: * Male volunteers * Age: between 20 and 45 years * Body mass index (BMI): 20 -26 kg/m2 * Agreement and signed consent before the study Exclusion Criteria: * Smoker * Competitive Athletes * Diabetes mellitus * Rheumatic disease * Muscle or joint disease * Bone fractures in the period up to one year before study start * Herniated disc * Flatfeet (pes planus) * Allergy to nuts or legume * Vascular diseases * Epilepsy * Severe hyperlipidemia * Anemia (\< Hb standard values; standard values healthy men: 13.5 -17.5 g/dl) \* * Increased thrombosis risk \* * Kidney disorder: deviations from normal values for creatinine in plasma. (Normal value: Creatinine \< 1.20 mg/dl)\* * Lesions of the cruciate ligaments, or orthopedic surgery in the past 10 years on the side of the Hephaistos orthosis * Achilles tendon injury, or rupture in the past 10 years on the side of the orthosis * hyper-/hypocalcaemia (abnormal levels of calcium in the blood, normal level: 2.15 - 2.64 mmol/l) * Intake of anti-inflammatory drugs during the study * Abuse of drugs or alcohol (\> than 20-30g alcohol/day) * Participation in another clinical study within the last 2 months before the start of this study * Increased bleeding tendency (hemophilia, regular use of anticoagulants) * History of intolerance to local anesthetics * Imprisoned during study * Any other condition classed as unsuitable for study participation by the medical executive director * prior convictions (objectionable criminal record) Additional Exclusion Criteria for MRI * Metal implants or other osteosynthesis material * Pacemaker * Claustrophobia